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Antibodies

Wnt-5a

Product Sizes
100 ug
£270.59
103-PA16-100UG
200 ug
£411.76
103-PA16-200UG
About this Product
SKU:
103-PA16
Additional Names:
Wnt-5a; Wnt5a; Wnt 5a; Wnt
Clonality:
Polyclonal
Extra Details:
Wnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt-5a has, until recently, lived in the shadow of its better-characterised relatives. This was largely because of its apparent inability to transform cells or signal through the canonical beta-catenin pathway that is so important in cancer, particularly colorectal cancer. Recent work in a wide range of human tumours has pointed to a critical role for Wnt-5a in malignant progression, but there is conflicting evidence whether Wnt-5a has a tumour-promoting or -suppressing role. Emerging evidence suggests that the functions of Wnt-5a can be drastically altered depending on the availability of key receptors. Hence, the presence or absence of these receptors may go some way to explain the conflicting role of Wnt-5a in different cancers.
Formulation:
lyophilized
Host:
Rabbit
Immunogen:
Recombinant mouse Wnt-5a
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Polyclonal Antibody