IL-21
Product Sizes
100 ug
£365.88
103-P77-100UG
About this Product
- SKU:
- 103-P77
- Additional Names:
- Il21
- Application:
- ELISA, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- Rabbit IgG
- Clonality:
- Polyclonal
- Extra Details:
- IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naive B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (°C) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
- Formulation:
- lyophilized from PBS
- Host:
- Rabbit
- Immunogen:
- Recombinant mouse IL-21
- Purification:
- Antigen-affinity purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Polyclonal Antibody