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Antibodies

ALK5

Product Sizes
100 ug
£674.12
103-M96-100UG
About this Product
SKU:
103-M96
Additional Names:
Tgfbr1; ALK5; Alk-5; TbetaRI; AU017191; TbetaR-I
Application:
Immunohistochemistry, Western Blot
Buffer:
PBS
translate.label.attr.clone:
3A11
Clonality:
Monoclonal
Extra Details:
Most cell types express three sizes of receptors for TGFB Beta. These are designated Type I (53 kDa), Type II (7085 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membranebound and soluble forms, binds TGFB Beta1, TGFB Beta2, and TGFB Beta3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane bound serine/threonine kinase that binds TGFB Beta1 and TGFB Beta3 with high affinity and TGFB Beta2 with a much lower affinity. The Type I receptor, originally known as ALK5 (Activin receptor-like kinase) is also a membranebound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGFB Beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recmobinant mouse ALK5 extracellular domain
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody