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Antibodies

ALK1

Product Sizes
100 ug
£674.12
103-M95-100UG
About this Product
SKU:
103-M95
Additional Names:
Acvrl1; Alk1; Acvrlk1; AI115505; AI427544
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
1B03
Clonality:
Monoclonal
Extra Details:
Transforming Growth Factor beta (TGFB Beta) superfamily ligands exert their biological activities via binding to heteromeric receptor complexes of two types (I and II) ofserine/threonine kinases. Type II receptors are constitutively active kinases that phosphorylate-type I receptors upon ligand binding. In turn, activated type I kinases phosphorylate downstream signaling molecules including the various smads. Transmembrane proteoglycans, including the type III receptor (betaglycan) and endoglin, can bind and present some of the TGFB Beta superfamily ligands to type I and II receptor complexes and enhance their cellular responses. Seven type I receptors (also termed activin receptor-like kinase (ALK)) and five type II receptors have been isolated from mammals. ALK2, 3, 4, 5, and 6 are also known as Activin R1A, BMPR1A, Activin R1B, TGFB Beta R1, and BMPR1B, respectively, reflecting their ligand preferences. Evidence suggests that TGFB Beta1, TGFB Beta3 and an unknown ligand present in serum can activate chimeric ALK1. ALK1 shares with other type I receptors a cysteine-rich domain with conserved cysteine spacing in the extracellular region, and a glycineand serine-rich domain (the GS domain) preceding the kinase domain. ALK1 is expressed highly in endothelial cells and other highly vascularized tissues. The expression patterns of ALK1 parallels that of endoglin. Mutations in ALK1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting a critical role for ALK 1 in the control of blood vessel development or repair. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular regions.
Formulation:
lyophilized
Host:
Rat
Immunogen:
human extracellular domain of ALK1
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody