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Antibodies

PIR-B

Product Sizes
100 ug
£674.12
103-M551-100UG
About this Product
SKU:
103-M551
Additional Names:
Leukocyte immunoglobulin-like receptor, subfamily B (With TM and ITIM domains), member 3, Pirb, Lilrb3
Application:
Flow Cytometry, Western Blot
Buffer:
PBS
translate.label.attr.clone:
3K39
Clonality:
Monoclonal
Extra Details:
Mouse PIR-B is a 125 kDa type I transmembrane glycoprotein with six Ig-like domains in its extracellular domain (ECD) and four ITIM-like sequences in its cytoplasmic domain. The ECD of PIR-B is highly homologous to the ECDs of multiple mouse PIR-A receptors (92-99% amino acid sequence homology), which have short cytoplasmic tails lacking ITIM motifs. PIR-A receptors have a charged residue in their transmembrane domain that facilitates interaction with ITAM-containing adaptor molecules. Whereas PIR-A receptors deliver activation signals, PIR-B can inhibit receptor-mediated activation signaling. PIR-A and PIR-B have been shown to bind various mouse MHC class I molecules. They have been proposed to be orthologs of human leukocyte immunoglobulin-like receptors.
Formulation:
lyophilized
Host:
Rat
Immunogen:
Recombinant Mouse PIR-B
Isotype:
IgG2
Purification:
Protein G Purified
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody