PIR-B
Product Sizes
100 ug
£674.12
103-M551-100UG
About this Product
- SKU:
- 103-M551
- Additional Names:
- Leukocyte immunoglobulin-like receptor, subfamily B (With TM and ITIM domains), member 3, Pirb, Lilrb3
- Application:
- Flow Cytometry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 3K39
- Clonality:
- Monoclonal
- Extra Details:
- Mouse PIR-B is a 125 kDa type I transmembrane glycoprotein with six Ig-like domains in its extracellular domain (ECD) and four ITIM-like sequences in its cytoplasmic domain. The ECD of PIR-B is highly homologous to the ECDs of multiple mouse PIR-A receptors (92-99% amino acid sequence homology), which have short cytoplasmic tails lacking ITIM motifs. PIR-A receptors have a charged residue in their transmembrane domain that facilitates interaction with ITAM-containing adaptor molecules. Whereas PIR-A receptors deliver activation signals, PIR-B can inhibit receptor-mediated activation signaling. PIR-A and PIR-B have been shown to bind various mouse MHC class I molecules. They have been proposed to be orthologs of human leukocyte immunoglobulin-like receptors.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- Recombinant Mouse PIR-B
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody