Convertase-9
Product Sizes
100 ug
£674.12
103-M520-100UG
About this Product
- SKU:
- 103-M520
- Additional Names:
- Proprotein convertase subtilisin/kexin type 9, Neural apoptosis-regulated convertase 1 (NARC-1), Proprotein convertase 9 (PC9), Subtilisin/kexin-like protease PC9
- Application:
- Immunoprecipitation, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 42Q2
- Clonality:
- Monoclonal
- Extra Details:
- PCSK9 (proprotein convertase subtilisin kexin 9), also known as NARC1, is a member of the proteinase K subfamily of subtilisin-related serine endoproteases. It is highly expressed in the liver, intestine, and kidney and plays an important role in regulating LDL R expression and circulating cholesterol levels. PCSK9 is synthesized as precursor protein that is autocatalytically cleaved in the endoplasmic reticulum to generate a 14 kDa prodomain and a 60 kDa catalytic domain. Within the secretion pathway, the prodomain remains associated with and functions as a chaperone for the catalytic domain. Mouse PCSK9 shares 78% and 93% amino acid identity with human and rat PCSK9, respectively. PCSK9 plays a key role in the regulation of cholesterol metabolism by binding to hepatic LDL R, LRP1, VLDL R, and Apolipoprotein E R2 and promoting their lysosomal degradation instead of recycling to the plasma membrane.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- Recombinant Mouse Proprotein Convertase-9
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody