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Antibodies

TNFRSF10B

Product Sizes
100 ug
£674.12
103-M478-100UG
About this Product
SKU:
103-M478
Additional Names:
Tnfrsf10b; MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B
Application:
IHC-Frozen, Western Blot
Buffer:
PBS
translate.label.attr.clone:
9K26
Clonality:
Monoclonal
Extra Details:
TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members. TRAIL binds at least five different receptors: TRAIL R1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAIL R1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAIL R1 and R2. TRAIL R3 is membrane-associated via GPI linkage. TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein.
Formulation:
lyophilized
Host:
Rat
Immunogen:
Mouse recombinant protein TNFRSF10B
Isotype:
IgG2
Purification:
Protein A/G Purified
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody