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Antibodies

PCPE-1

Product Sizes
100 ug
£674.12
103-M450-100UG
About this Product
SKU:
103-M450
Additional Names:
Pcolce; P14; Astt2; Astt-2; PCPE-1
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
7H78
Clonality:
Monoclonal
Extra Details:
Procollagen Cendopeptidase enhancers, known as PCPEs or PCOLCEs, are secreted extracellular matrix glycoproteins that consist of two CUB domains and one NTR domain. They are known to stimulate enzymatic cleavage of procollagens IIII by the BMP-1/ tolloid family of metallo-proteases, also known as procollagen Cproteinases. PCPE1 is expressed primarily by interstitial connective tissues such as tendons, calvaria, and skin. Although BMP1/ tolloid proteinases are involved in processing of multiple extracellular proteins, the enhancer activity of PCPE1 is specific to procollagens since it has no effect on BMP1/ tolloid cleavage of other substrates. It is thought that PCPE1 enhances cleavage of procollagens by binding to the substrate, inducing a conformation change in the substrate, although interaction between PCPE-1 and fulllength BMP-1/ tolloid proteinases has also been reported.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recombinant mouse PCPE-1
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody