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Antibodies

P-Cadherin

Product Sizes
100 ug
£674.12
103-M449-100UG
About this Product
SKU:
103-M449
Additional Names:
Cdh3; Cadp; Pcad; AI385538; P-cadherin
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
9J47
Clonality:
Monoclonal
Extra Details:
Placental Cadherin (PCadherin or PCAD) is a member of the cadherin family of cell adhesion molecules. Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, A Alpha, B Beta, and G Gamma (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. P Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. Constitutive P Cadherin expression is found in the epidermis, mesothelium, corneal epithelium, and uterine decidua. Mouse PCadherin is an 822 amino acid (aa) protein with a 27 aa signal sequence and a 795 aa propeptide. The mature protein begins at aa 100 and has a 542 aa extracellular region, a 27 aa transmembrane region, and a 153 aa cytoplasmic region.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recombinant mouse P-Cadherin extracellular domain
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody