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Antibodies

Ephrin-A4

Product Sizes
100 ug
£674.12
103-M377-100UG
About this Product
SKU:
103-M377
Additional Names:
Efna4
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
8K23
Clonality:
Monoclonal
Extra Details:
EphrinA4, also known as LERK4 and EFL4 (1), is a member of the ephrin ligand family which binds members of the Eph receptor family. All ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines. The A-class ligands have a GPI anchor following the conserved sequence. EphrinA4 has been shown to bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. The extracellular domains of human and mouse EphrinA4 share 80% amino acid identity. Only membrane-bound or Fc clustered ligands are capable of activating the receptor in vitro. While soluble monomeric ligands bind the receptor, they do not induce receptor autophosphorylation and activation. In vivo, the ligands and receptors display reciprocal expression. It has been found that nearly all receptors and ligands are expressed in developing and adult neural tissue. The Eph/ephrin families also appear to play a role in angiogenesis.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recombinant mouse protein Ephrin-A4
Isotype:
IgG2
Purification:
Protein G/A chromatography
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody