CCL-3
Product Sizes
100 ug
£674.12
103-M333-100UG
About this Product
- SKU:
- 103-M333
- Additional Names:
- Ccl3; Mip1a; Scya3; G0S19-1; AI323804; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha
- Application:
- Block/Inhibit/Neutralise, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 5F17
- Clonality:
- Monoclonal
- Extra Details:
- The macrophage inflammatory proteins 1A Alpha (or CCL3) and 1B Beta, two closely related but distinct proteins, were originally co purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1A Alpha shares approximately 77% and 70% amino acid identity with human MIP1A Alpha and mouse MIP1B Beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. The MIP1 proteins are members of the B Beta (CC) subfamily of chemokines. Both MIP1A Alpha and MIP1B Beta are monocyte chemoattractants in vitro. Additionally, the MIP1 proteins have been reported to have chemoattractant and adhesive effects on lymphocytes, with MIP1A Alpha and MIP1B Beta preferentially attracting CD8+ and CD4+ T cells, respectively. MIP1A Alpha has also been shown to attract B cells as well as eosinophils. MIP1 proteins have been reported to have multiple effects on hematopoietic precursor cells and MIP1A Alpha has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. In the same assays, MIP1B Beta was reported to be much less active. The functional receptor for MIP1A Alpha has been identified as CCR1 and CCR5.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse CCL-3
- Isotype:
- IgG2
- Purification:
- Protein G/A chromatography
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody