Cathepsin L
Product Sizes
100 ug
£674.12
103-M319-100UG
About this Product
- SKU:
- 103-M319
- Additional Names:
- Ctsl; fs; MEP; nkt; Ctsl1; 1190035F06Rik
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 5G14
- Clonality:
- Monoclonal
- Extra Details:
- Cathepsin L is a lysosomal cysteine protease expressed in most eukaryotic cells. Cathepsin L is known to hydrolyze a number of proteins, including the proform of urokinasetype plasminogen activator, which is activated by Cathepsin L cleavage. Cathepsin L has also been shown to proteolytically inactivate A Alpha1antitrypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract. These observations, combined with the demonstration of increased Cathepsin L activity in the epithelial lining fluid of the lungs of emphysema patients, have led to the suggestion that the enzyme may be involved in the progression of this disease. Cathepsin L has also been identified as a major excreted protein of transformed fibroblasts, indicating the enzyme could be involved in malignant tumor growth. In Cathepsin L deficient mice, it appears to play a critical role in cardiac morphology and function, epidermal homeostasis, regulation of the hair cycle, and MHC class I-mediated antigen presentation in cortical epithelial cells of the thymus. Mouse Cathepsin L is synthesized as a 334 amino acid precursor with a signal peptide (residues 117), a pro region (residues 18-113), and a mature chain (residues 114-334).
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse Cathepsin-L
- Isotype:
- IgG2
- Purification:
- Protein G/A chromatography
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody