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Antibodies

Cathepsin D

Product Sizes
100 ug
£674.12
103-M315-100UG
About this Product
SKU:
103-M315
Additional Names:
Ctsd; CD; CatD
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
7D22
Clonality:
Monoclonal
Extra Details:
Cathepsin D is a lysosomal aspartic protease of the pepsin family. Mouse Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 120), a propeptide (residues 21-64), and a mature chain (residues 65-410). It is expressed in most cells and overexpressed in breast cancer cells. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in this enzyme showed a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells is responsible for the generation of angiostatin, a potent endogeneous inhibitor of angiogenesis.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recombinant mouse Cathepsin-D
Isotype:
IgG2
Purification:
Protein G/A chromatography
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody