Cathepsin D
Product Sizes
100 ug
£674.12
103-M315-100UG
About this Product
- SKU:
- 103-M315
- Additional Names:
- Ctsd; CD; CatD
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 7D22
- Clonality:
- Monoclonal
- Extra Details:
- Cathepsin D is a lysosomal aspartic protease of the pepsin family. Mouse Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 120), a propeptide (residues 21-64), and a mature chain (residues 65-410). It is expressed in most cells and overexpressed in breast cancer cells. It is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in this enzyme showed a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells is responsible for the generation of angiostatin, a potent endogeneous inhibitor of angiogenesis.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse Cathepsin-D
- Isotype:
- IgG2
- Purification:
- Protein G/A chromatography
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody