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Antibodies

Cathepsin B

Product Sizes
100 ug
£674.12
103-M314-100UG
About this Product
SKU:
103-M314
Additional Names:
Ctsb; CB
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
6C15
Clonality:
Monoclonal
Extra Details:
Cathepsin B (CTSB) is a papain-family cysteine protease that is normally located in lysosomes, and is a member of a superfamily of structurally similar tissue proteinases having a 25 kDa catalytic unit. Cathepsin B is synthesized as a preproenzyme and the primary pathways for its normal trafficking to the lysosome utilize mannose 6-phosphate receptors (MPRs). Mature cathepsin B has the ability to degrade several extracellular matrix components at both neutral and acidic pH and has been implicated in the progression of several human and rodent tumors progression and arthritis. Overexpression and altered trafficking of cathepsin B characterize the malignant phenotype of tumor cells, and thus CTSB is suggested as a tumor marker.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recombinant mouse Cathepsin-B
Isotype:
IgG1
Purification:
Protein G/A chromatography
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody