Cardiotrophin-1
Product Sizes
100 ug
£674.12
103-M309-100UG
About this Product
- SKU:
- 103-M309
- Additional Names:
- Ctf1; CT-1
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 1J24
- Clonality:
- Monoclonal
- Extra Details:
- Cardiotrophin1 (CT1) is a member of the cytokine family which also includes IL6, IL11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL6 family members on a variety of cell types. Mouse CT1 encodes a 203 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. The mechanism of CT 1 release from cells is currently not understood. Human and mouse CT1 share 80% aa sequence identity and exhibit crossspecies activity. CT1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels of CT1 expression is also seen in testis and brain. CT 1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor B Beta subunit. A third A Alpha receptor subunit has also been implicated in the receptor complex.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse Cardiotrophin-1
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody