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Antibodies

TREM-1

Product Sizes
100 ug
£674.12
103-M279-100UG
About this Product
SKU:
103-M279
Additional Names:
TREM1
Application:
IHC-Frozen, Western Blot
Buffer:
PBS
translate.label.attr.clone:
3C66
Clonality:
Monoclonal
Extra Details:
TREM1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Iglike domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM1 is expressed on blood neutrophils and a subset of monocytes, and expression is upregulated by bacterial LPS. Engagement of TREM1 with a monoclonal antibody leads to expression of IL8, MCP1, and TNFA Alpha suggesting that this receptor plays an important role in inflammatory responses. TREM1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with LPS induced shock. Blockade of TREM1 with a TREM1/ Fc fusion protein protected mice against LPS induced shock.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recombinant mouse extracellular domain of TREM-1
Isotype:
IgG2
Purification:
Protein A/G Purified
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody