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Antibodies

IL-20 receptor alpha

Product Sizes
100 ug
£674.12
103-M249-100UG
About this Product
SKU:
103-M249
Additional Names:
Il20ra, E230031K19
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
11C42
Clonality:
Monoclonal
Extra Details:
IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland. The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells. IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals. IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26. Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes.
Formulation:
lyophilized
Host:
Rat
Immunogen:
Mouse recombinant EC domain of IL-20 R alpha
Isotype:
IgG1
Purification:
Protein A/G Purified
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody