IL-20 receptor alpha
Product Sizes
100 ug
£674.12
103-M249-100UG
About this Product
- SKU:
- 103-M249
- Additional Names:
- Il20ra, E230031K19
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 11C42
- Clonality:
- Monoclonal
- Extra Details:
- IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland. The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells. IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals. IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26. Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- Mouse recombinant EC domain of IL-20 R alpha
- Isotype:
- IgG1
- Purification:
- Protein A/G Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody