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Antibodies

EDAR (ectodysplasmin receptor)

Product Sizes
100 ug
£674.12
103-M219-100UG
About this Product
SKU:
103-M219
Additional Names:
Edar; dl; ED3; ED5; ED1R; EDA3; EDA-A1R
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
8L53
Clonality:
Monoclonal
Extra Details:
EDAR is a type I transmembrane protein which is a member of the TNF Receptor Superfamily (TNFR-SF). The extracellular domain contains 14 cysteine residues, six of which approximate the TNFRSF cysteine-rich region, the cytoplasmic domain contains a region with homology to the death domains found in other TNFRSF members. Mouse EDAR is a 488 amino acid (aa) protein with a predicted 30 aa signal, a 159 aa extracellular domain, a 22 aa transmembrane domain, and a 277 aa cytoplasmic domain. The human and mouse EDAR homologs share 91% identity. Within the TNFRSF, EDAR shares the highest homologies with XEDAR and TNFRSF19/TROY. EDAA1 is the EDAR ligand. EDA and EDAR have been associated with hypohidrotic ectodermal dysplasia (HED). HED is characterized by abnormalities in hair, teeth and eccrine sweat gland morphogenesis. HED was initially found to associate with two gene loci, tabby and downless. Tabby was later identified as the gene for EDA and downless as the autosomal EDAR gene. EDA has two splice variants, EDAA1 and EDAA2 which differ by only two amino acids. Despite this minor difference, the EDA isoforms display strong receptor specificity. EDAA1 only binds to EDAR, whereas EDAA2 binds to XEDAR, an Xlinked TNFRSF member with high homology to EDAR. Mutations in EDA, EDAR and XEDAR have been associated with HED.
Formulation:
lyophilized
Host:
Rat
Immunogen:
recombinant mouse EC-domain of EDAR
Isotype:
IgG2
Purification:
Protein G/A chromatography
Reactivities:
Mouse
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody