Artemin
Product Sizes
100 ug
£674.12
103-M216-100UG
About this Product
- SKU:
- 103-M216
- Additional Names:
- Artn; neublastin
- Application:
- Immunohistochemistry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 6D32
- Clonality:
- Monoclonal
- Extra Details:
- Artemin is a member of the Glia Cel-lDerived Neurotrophic factor (GDNF) family ligands, which include GDNF, Persephin, Artemin, and Neurturin. GDNF family ligands are distant members of the Transforming Growth Factor B Beta (TGFB Beta) superfamily. Similar to other TGFB Beta family proteins, Artemin is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. The carboxy terminal domain of Artemin contains the characteristic seven conserved cysteine residues necessary for the formation of the cysteine-knot and the single interchain disulfide bond. Biologically active Artemin is a disulfide-linked homodimer of the carboxyterminal 113 amino acid residues. Mature mouse Artemin shares 88.5% amino acid sequence similarity with human Artemin. Mature Artemin also shares approximately 40% amino acid sequence identity with the other three members of the GDNF family ligands. Bioactivities of all GDNF family ligands are mediated through a receptor complex composed of a high affinity ligand binding component (GFRA Alpha1GFRA Alpha4) and a common signaling component, cRET (receptor tyrosine kinase). Artemin prefers to bind to GFRA Alpha3 and activites the GFRA Alpha3RET. However, in the presence of RET, it can bind to GFRA Alpha1 as well. Artemin has been shown to promote the survival and growth of various peripheral and central neurons, including sympathetic and dopaminergic neurons. It may also play an important role in the development of sympathetic neurons and several organs.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- recombinant mouse Artemin
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody