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Antibodies

SMCY/JARID1D

Product Sizes
100 ug
£270.59
102-PA86-100UG
200 ug
£411.76
102-PA86-200UG
About this Product
SKU:
102-PA86
Additional Names:
KDM5D lysine (K)-specific demethylase 5D, HY; HYA
Application:
Western Blot
Buffer:
PBS
Clonality:
Polyclonal
Extra Details:
H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Muellerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available.
Formulation:
lyophilized
Host:
Rabbit
Immunogen:
Recombinant human SMCY (RT #300-064)
Purification:
Protein A Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Polyclonal Antibody