Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Antibodies

CD105/Endoglin

Product Sizes
100 ug
£270.59
102-PA60-100UG
200 ug
£411.76
102-PA60-200UG
About this Product
SKU:
102-PA60
Additional Names:
Endoglin; END; ORW; HHT1; ORW1; CD105
Application:
ELISA, Flow Cytometry, Immunofluorescence, Western Blot
Buffer:
PBS
translate.label.attr.clone:
(#6D46)
Clonality:
Polyclonal
Extra Details:
Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human Endoglin, the S-Endoglin and L-Endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse Endoglin share approximately 70% and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart development. Mutations in human Endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for Endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.
Formulation:
lyophilized
Host:
Rabbit
Immunogen:
Recombinant human sCD105/Endoglin (RT #S01-025)
Purification:
Protein A Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Polyclonal Antibody