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Antibodies

Dkk-1

Product Sizes
100 ug
£270.59
102-PA33-100UG
200 ug
£411.76
102-PA33-200UG
About this Product
SKU:
102-PA33
Additional Names:
Dickkopf-related protein-1, Dickkopf-1, SK
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
(#7K51)
Clonality:
Polyclonal
Extra Details:
DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /B Beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/B Betacatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/B Betacatenin signaling cascade. It has been suggested that by inhibiting Wnt/B Beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.
Formulation:
lyophilized
Host:
Rabbit
Immunogen:
recombinant human Dkk-1
Purification:
Protein A Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Polyclonal Antibody