Galectin-1
Product Sizes
100 ug
£270.59
102-PA131-100UG
200 ug
£411.76
102-PA131-200UG
About this Product
- SKU:
- 102-PA131
- Additional Names:
- LGALS1; GBP; GAL1
- Application:
- Western Blot
- Buffer:
- 3 mM PBS, pH 7.2
- Clonality:
- Polyclonal
- Extra Details:
- Galectin-1, also known as L14, BHL and galaptin, is a monomeric or homodimeric prototype galectin that is expressed in a variety of cells and tissues including muscle, heart, liver, prostate, lymph nodes, spleen, thymus, placenta, testis, retina, macrophages, B cells, T cells, dendritic cells, and tumor cells. It preferentially binds laminin, fibronectin, 90K/Mac2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth and proliferation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting proinflammatory cytokine production. Galectin1 can also modulate cel-lcell as well as cell-lmatrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and antiinflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity. Human and mouse galectin1 share about 88% amino acid sequence similarity.
- Formulation:
- lyophilized
- Host:
- Rabbit
- Immunogen:
- Recombinant human Galectin-1 (RT #100-175)
- Purification:
- Protein A Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Polyclonal Antibody