IL-1 alpha
Product Sizes
100 ug
£365.88
102-P30-100UG
About this Product
- SKU:
- 102-P30
- Additional Names:
- IL1A; IL1; IL-1A; IL1F1; IL1-ALPHA
- Application:
- Block/Inhibit/Neutralise, ELISA, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- IL1A Alpha and IL1B Beta are both synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17,000 Da. Neither precursor contains a typical hydrophobic signal peptide sequence and most of the precursor form of IL1A Alpha remains in the cytosol of cells, although there is evidence for a membranebound form of the precursor form of IL1A Alpha. The IL1A Alpha precursor reportedly shows full biological activity in the EL4 assay. Among various species, the amino acid sequence of mature IL 1A Alpha is conserved 60% to 70% and human IL1 has been found to be biologically active on murine cell lines. Both forms of IL1 bind to the same receptors, designated type I and type II. Evidence suggests that only the type I receptor is capable of signal transduction and that the type II receptor may function as a decoy, binding IL1 and thus preventing binding of IL1 to the type I receptor.
- Formulation:
- lyophilized from PBS
- Host:
- Rabbit
- Immunogen:
- Recombinant human IL-1 alpha
- Purification:
- Antigen-affinity purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Polyclonal Antibody