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Antibodies

TIMP-1

Product Sizes
100 ug
£365.88
102-P252-100UG
About this Product
SKU:
102-P252
Additional Names:
TIMP1; EPA; EPO; HCI; CLGI; TIMP
Application:
ELISA, Western Blot
Buffer:
PBS
Clonality:
Polyclonal
Extra Details:
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Formulation:
lyophilized from PBS
Host:
Rabbit
Immunogen:
recombinant human TIMP-1
Purification:
Antigen-affinity purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Polyclonal Antibody