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Antibodies

CD22

Product Sizes
100 ug
£365.88
102-P107-100UG
About this Product
SKU:
102-P107
Additional Names:
CD22; SIGLEC2; SIGLEC-2
Application:
ELISA, Western Blot
Buffer:
PBS
translate.label.attr.clone:
(#3F67)
Clonality:
Polyclonal
Extra Details:
Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
Formulation:
lyophilized from PBS
Host:
Rabbit
Immunogen:
CHO cells derived Recombinant Human sCD22
Purification:
Antigen-affinity purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Polyclonal Antibody