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Antibodies

4-1BB receptor

Product Sizes
100 ug
£365.88
102-P100G-100UG
About this Product
SKU:
102-P100G
Additional Names:
TNFRSF9; ILA; 4-1BB; CD137; CDw137
Application:
ELISA, Western Blot
Buffer:
PBS
Clonality:
Polyclonal
Extra Details:
4-1BB (or human 4-1BBL receptor) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is alternatively known as TNFR-SF9, CD137, and ILA. The 255 amino acid is a type I transmembrane protein having in its extracellular domain four of the cysteine-rich motifs that are characteristic of the TNF receptor superfamily. The 30 kDa glycoprotein exists both as a monomer and as a dimer on T cells. The human and mouse proteins share 60% amino acid identity. 4-1BB is absent from naive T cells, but it is upregulated and continually expressed following T cell activation. The natural ligand, 4-1BBL, is a member of the TNF superfamily and is expressed on activated antigen presenting cells including dendritic cells, macrophages, and B cells. Crosslinking of 4-1BB by 4-1BBL or by agonistic antibodies transmits a potent co stimulatory signal that enhances the effect of other activating signals such as PHA or antiCD3 antibodies. 4-1BB signals through the TFAF2NIK pathway resulting in activation of NFK KappaB and ultimately promoting proliferation and survival of T cells.
Formulation:
lyophilized from PBS
Host:
Goat
Immunogen:
highly pure (>98%) recombinant human 4-1BB Receptor
Purification:
Antigen-affinity purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Polyclonal Antibody