BMP-2
Product Sizes
100 ug
£365.88
102-P03A-100UG
About this Product
- SKU:
- 102-P03A
- Additional Names:
- bone morphogenetic protein 2; BDA2; BMP2A; bone morphogenetic protein 4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
- Application:
- ELISA, Western Blot
- Buffer:
- PBS
- Clonality:
- Polyclonal
- Extra Details:
- Human BMP-2 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor B Beta (TGFB Beta) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Similarly to other TGFB Beta family proteins, BMPs are highly conserved across animal species. At the amino acid sequence level, mature human, mouse and rat BMP2 are 100% identical. BMP2 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. Biologically active BMP 2 is a disulfidelinked homodimer of the carboxyterminal 114 amino acid residues that contains the characteristic seven conserved cysteine residues involved in the formation of the cysteine knot and the single interchain disulfide bond. Cellular responses to BMP2 have been shown to be mediated by the formation of heterooligomeric complexes of type I and type II serine/threonine kinase receptors. One BMP type II and two BMP type I receptors have been identified. In contrast to the TGFB Beta type I receptor, which does not bind the ligand in the absence of the TGFB Beta receptor type II, both BMP receptor type Is can bind BMP2 with highaffinity in the absence of BMP receptor type II.
- Formulation:
- lyophilized from PBS
- Host:
- Rabbit
- Immunogen:
- E.coli derived Recombinant Human BMP-2
- Purification:
- Antigen-affinity purified
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Polyclonal Antibody