TIE-2
Product Sizes
50 ug
£270.59
101-MBi54-50UG
About this Product
- SKU:
- 101-MBi54
- Additional Names:
- TEK; TIE2; VMCM; TIE-2; VMCM1; CD202B
- Application:
- ELISA, Flow Cytometry
- Buffer:
- PBS
- translate.label.attr.clone:
- tek16
- Clonality:
- Monoclonal
- Conjugate:
- Biotin
- Extra Details:
- Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human soluble extracellular TIE-2
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody