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Antibodies

Cerberus-2 (COCO)

Product Sizes
100 ug
£674.12
101-M860-100UG
About this Product
SKU:
101-M860
Additional Names:
Gremlin-2, Cysteine knot superfamily 1, BMP antagonist 2, DAN domain family member 3, Protein related to DAN and cerberus, GREM2
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
5P25
Clonality:
Monoclonal
Extra Details:
COCO, also known as DAND5, Dante, and CKTSF1B3, is a member of the DAN Domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), and Cerberus (DAND4). DAN family members contain a cysteine-knot domain that is homologous to that found in other TGF-beta superfamily ligands. BMPs play important roles in tissue morphogenesis and development processes. The human COCO cDNA encodes a 189 amino acid (aa) precursor with a 22 aa signal sequence. COCO has eight Cys residues in the cysteine-knot which places it in the CAN subfamily of BMP antagonists along with the other DAN family proteins. COCO binds and inhibits Xnr1, BMP-4, Activin, and Wnt-8. In mouse, COCO expression is elevated on the right side of Henson's node at the early somite stage, in contrast to the left side expression of Nodal (8). COCO may cooperate with Nodal in gastrulation and embryonic left-right axis formation.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
Recombinant Human COCO
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody