TIMP-2
Product Sizes
100 ug
£674.12
101-M838-100UG
About this Product
- SKU:
- 101-M838
- Additional Names:
- TIMP2; CSC-21K
- Buffer:
- PBS
- translate.label.attr.clone:
- 2C64
- Clonality:
- Monoclonal
- Extra Details:
- TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- human recombinant TIMP-2 protein
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody