PDGFR-alpha
Product Sizes
100 ug
£674.12
101-M824-100UG
About this Product
- SKU:
- 101-M824
- Additional Names:
- PDGFRA; CD140A; PDGFR2; PDGFR-2; RHEPDGFRA
- Application:
- Flow Cytometry, Immunoprecipitation
- Buffer:
- PBS
- translate.label.attr.clone:
- 8A12
- Clonality:
- Monoclonal
- Extra Details:
- PDGF is a major serum mitogen that can exist as a homo- or heterodimeric protein consisting of disulfidelinked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Whereas PDGF RA Alpha binds all three PDGF isoforms with high affinity, PDGF RB Beta binds PDG-FBB and AB, but not PDGFAA. Both PDGF RA Alpha and PDGF RB Beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for MCSF, SCF and Flt3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the A Alpha and B Beta receptors is independently regulated in various cell types. Only PDGF RA Alpha is expressed in oligodendrocyte progenitor cells, mesothelial cell and liver endothelial cells. Soluble PDGFRA Alpha has been detected in cell conditioned medium and human plasma. Recombinant soluble PDGF RA Alpha binds PDGF with high affinity and is a potent PDGF antagonist.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- N-terminal recombinant human PDGFR alpha fragment
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody