MMP-8
Product Sizes
100 ug
£674.12
101-M811-100UG
About this Product
- SKU:
- 101-M811
- Additional Names:
- MMP8; HNC; CLG1; MMP-8; PMNL-CL
- Application:
- Flow Cytometry, IHC-Paraffin, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 7A65
- Clonality:
- Monoclonal
- Extra Details:
- Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP8 (neutrophil collagenase) is expressed in neutrophils, where it is stored in specific granules. MMP8 release from the neutrophils is stimulated by various factors such as interleukins 1 and 8, TNFA Alpha and GM-CSF. MMP8 is capable of cleaving types I, II and III triplehelical collagen, gelatin peptides, fibronectin, proteoglycans, aggrecan, serpins, B Betacasein and peptides such as angiotensin and substance P. In addition to its function in phagocytosis, MMP8 has a high capacity for infiltrating connective tissue, and is implicated in the breakdown of the extracellular matrix in diseases such as rheumatoid arthritis. Structurally, MMP8 consists of several domains: a prodomain that is cleaved upon activation, a catalytic domain containing the zinc-binding site, a short hinge region and a hemopexinlike domain. MMP8 is heavily glycosylated.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human MMP-8
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody