Legumain
Product Sizes
100 ug
£674.12
101-M801-100UG
About this Product
- SKU:
- 101-M801
- Additional Names:
- Legumain, Asparaginyl endopeptidase, Protease, cysteine 1
- Application:
- ELISA, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 46I3
- Clonality:
- Monoclonal
- Extra Details:
- Legumain is a protein that in humans is encoded by the LGMN gene. This gene encodes a cysteine protease, legumain, that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Recombinant Human Legumain
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody