Interferon gamma (IFN) R1
Product Sizes
100 ug
£674.12
101-M799-100UG
About this Product
- SKU:
- 101-M799
- Additional Names:
- Interferon gamma receptor 1, IFN-gamma receptor 1; IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain (IFN-gamma-R-alpha), CD119
- Application:
- Block/Inhibit/Neutralise, Flow Cytometry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 7K51
- Clonality:
- Monoclonal
- Extra Details:
- The high-affinity IFN-gamma receptor complex is made up of two type I membrane proteins, IFN-gamma R1 (IFN-gamma R alpha) and IFN-gamma R2 (IFN-gamma R beta). Both proteins are members of the type II cytokine receptor family and share approximately 52% amino acid sequence identity. IFN-gamma R1 is the ligand-binding subunit that is necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma R2 is required for IFN-gamma signalling but does not bind IFN-gamma by itself. Human IFN-gamma R1 cDNA encodes a 499 amino acid (aa) residue protein with a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Human and mouse IFN-gamma R1 share 52% amino acid sequence identity and bind IFN-gamma in a species-specific manner. IFN-gamma R1 is constitutively expressed in most cell types. Soluble IFN-gamma R1 that binds IFN-gamma has been detected in biological fluids.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Human recombinant IFN gamma RI EC domain
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody