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Antibodies

IL-5R alpha EC

Product Sizes
100 ug
£674.12
101-M792-100UG
About this Product
SKU:
101-M792
Additional Names:
Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA, CDw125, CD125
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
6J30
Clonality:
Monoclonal
Extra Details:
Interleukin-5 Receptor alpha (IL-5 R alpha ), also known as CD125, is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL-5 R alpha consists of a 322 amino acid (aa) extracellular domain (ECD) with a WSxWS motif and a four-cysteine motif, a 20 aa transmembrane segment, and a 58 aa cytoplasmic domain. Within the ECD, human IL-5 R alpha shares 71% aa sequence identity with mouse and rat IL-5 R alpha. Alternate splicing of human IL-5 R alpha generates soluble secreted forms which function as IL-5 antagonists. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 R alpha and the transmembrane common beta chain (beta c/CD131) which is shared with the receptor complexes for IL-3 and GM-CSF. IL-5 R alpha binds IL-5 at low affinity and then associates with preformed beta c oligomers to form the signalling-competent receptor complex.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
Human recombinant IL-5RalphaEC domain
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody