HAI-1
Product Sizes
100 ug
£674.12
101-M767-100UG
About this Product
- SKU:
- 101-M767
- Additional Names:
- SPINT1; HAI; HAI1; MANSC2
- Buffer:
- PBS
- translate.label.attr.clone:
- 3X89
- Clonality:
- Monoclonal
- Extra Details:
- HAI1 is a Kunitz-type serine protease inhibitor, identified as a strong inhibitor of HGF activator (HGFA) and matriptase. The membrane anchored HAI1 consists of two Kunitz domains, a LDL receptorlike domain, and a C-terminal transmembrane domain. Two soluble forms are generated by ectodomain shedding, one with a single Kunitz domain and the other with two Kunitz domains. HAI1 is not only an inhibitor but also a specific receptor of active HGFA, acting as a reservoir of this enzyme on the cell surface . The shedding of HAI1 and HGFA/HAI1 complex is enhanced by treatment with phorbol 12-myristate 13-acetate or IL1B Beta. The regulated shedding is completely inhibited by a synthetic zinc metalloprotease inhibitor.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human HAI-1 EC domain
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody