Gas-1
Product Sizes
100 ug
£674.12
101-M751-100UG
About this Product
- SKU:
- 101-M751
- Additional Names:
- Growth arrest-specific protein 1
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 3H43
- Clonality:
- Monoclonal
- Extra Details:
- Gas1 (Growth Arrest Specific 1) is one of six structurally unrelated proteins that were identified by their increased expression in growth-arrested cells relative to actively proliferating cells. Following mitogenic stimulation, Gas1 expression is transcriptionally suppressed by c-Myc as cells transit from G0 to G1 phases of the cell cycle. Overexpression of Gas1 prevents S phase entry and DNA synthesis. Gas1-mediated blockade of the cell cycle is p53-dependent but does not require the transactivating domain of p53. The human Gas1 cDNA encodes a 345 amino acid (aa) precursor that includes a 39 aa signal sequence, a 279 aa mature protein, and a 27 aa C-terminal propeptide. Gas1 contains Ala-rich and Asp-rich regions as well as an RGD sequence. Mature human and mouse Gas1 share 85% aa sequence identity. Human Gas1 is a 40 kDa GPI-linked glycoprotein that is uniformly distributed on the cell surface. In contact-inhibited vascular endothelial cells, Gas1 is induced by VE-Cadherin and VEGF expression and mediates the anti-apoptotic effect of VEGF.
- Formulation:
- lyophilized
- Host:
- Rat
- Immunogen:
- Recombinant human Gas-1
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody