TNFRSF10D
Product Sizes
100 ug
£674.12
101-M654-100UG
About this Product
- SKU:
- 101-M654
- Additional Names:
- TNFRSF10D; DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4
- Application:
- Block/Inhibit/Neutralise, Flow Cytometry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 6G9
- Clonality:
- Monoclonal
- Extra Details:
- TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members. TRAIL binds at least five different receptors: TRAIL R1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAIL R1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAIL R1 and R2. TRAIL R3 is membrane-associated via GPI linkage. TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Human recombinant TNFRSF10D EC domain
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody