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Antibodies

P-Cadherin

Product Sizes
100 ug
£674.12
101-M601-100UG
About this Product
SKU:
101-M601
Additional Names:
CDH3; CDHP; HJMD; PCAD
Application:
Flow Cytometry, Immunohistochemistry, Western Blot
Buffer:
PBS
translate.label.attr.clone:
9V11
Clonality:
Monoclonal
Extra Details:
Placental (P) Cadherin (PCAD) is a member of the Cadherin family of cell adhesion molecules. Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, A Alpha, B Beta, and G Gamma (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. P Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a singlepass transmembrane domain, and a short carboxyterminal cytoplasmic domain responsible for interacting with the catenins. Human P Cadherin is an 829 amino acid (aa) protein with a 26 aa signal sequence and an 803 aa propeptide. The mature protein begins at aa 108 and has a 548 aa extracellular region, a 23 aa transmembrane region, and a 151 aa cytoplasmic region. The human and mouse mature PCAD proteins share 87% homology.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
recombinant human P-Cadherin extracellular domain
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody