Pappalysin-2
Product Sizes
100 ug
£674.12
101-M600-100UG
About this Product
- SKU:
- 101-M600
- Additional Names:
- PAPPA2; PAPPE; PLAC3; PAPP-A2
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 8M12
- Clonality:
- Monoclonal
- Extra Details:
- Pappalysins belong to a fifth family of metzincin proteases that consists of ADAMs/ADAMTSs, MMPs, astacins and serrylysins. PAPPA is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy as compared to the non-pregnant state. PAPPA is also a major marker of Down syndrome in the first trimester of pregnancy because maternal serum levels of PAPPA are significantly reduced when a fetus affected by Down syndrome is present. PAPPA cleaves Insulin-like Growth FactorBinding Protein4 and 5 (IGFBP4 and 5) at a single site, resulting in the release of bioactive IGF. Compared to PAPPA, PAPPA2 (also called PAPPE), the second member of the family is less characterized. PAPPA2 shares 45% amino acid identity to PAPPA in the mature form, which is synthesized as a preproprotein consisting of multiple domains. The prepro region (residues 1-233) and the C-terminal region (residues 1397-1791) are not included in recombinant human PAPPA2.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human Pappalysin-2
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody