Orexin A
Product Sizes
100 ug
£674.12
101-M595-100UG
About this Product
- SKU:
- 101-M595
- Additional Names:
- Orexin A
- Application:
- IHC-Frozen
- Buffer:
- PBS
- translate.label.attr.clone:
- 8G22
- Clonality:
- Monoclonal
- Extra Details:
- There are two types of orexin: orexin-A and -B (hypocretin-1 and -2). They are excitatory neuropeptide hormones with approximately 50% sequence identity, are produced by cleavage of a single precursor protein. Orexin-A is 33 amino acid residues long and has two intrachain disulfide bonds; orexin-B is a linear 28 amino acid residue peptide. Studies suggest that orexin-A may be of greater biological importance than orexin-B. Although these peptides are produced by a very small population of cells in the lateral and posterior hypothalamus, they send projections throughout the brain. The orexin peptides bind to the two G-protein coupled orexin receptors, OX1 and OX2, with orexin-A binding to both OX1 and OX2 with approximately equal affinity while orexin-B binds mainly to OX2 and is 5 times less potent at OX1. The orexins are strongly conserved peptides, found in all major classes of vertebrates.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- human Orexin-A peptide (aa35-65, O43612)
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody