MBL
Product Sizes
100 ug
£674.12
101-M562-100UG
About this Product
- SKU:
- 101-M562
- Additional Names:
- MBL2; MBL; MBP; MBP1; MBL2D; MBP-C; COLEC1; HSMBPC
- Application:
- Block/Inhibit/Neutralise, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 4J25
- Clonality:
- Monoclonal
- Extra Details:
- Human mannose/mannan-binding lectin (MBL; also MBPC) is a 25 kDa member of the collectin family of pattern-recognition molecules. It is a secreted glycoprotein that is synthesized as a 248 amino acid (aa) precursor that contains a 20 aa signal sequence, a 21 aa cysteinerich region (with three cysteines) a 58 aa collagenlike segment and a 111 aa Ctype lectin domain that binds to neutral bacterial carbohydrates. The molecule is O glycosylatedand contains multiplehydroxylated prolines and lysines. Functionally, the molecule operates as a multimer/oligomer. The basic structural unit is a homotrimer. The homotrimer iscreated by the formation of interchain disulfide bonds among the cysteinerichregions, plus a helical interaction of the collagen-like domains of each participating polypeptide. Mutations in the collagen region are known to interfere with proper trimer and subsequent oligomer formation. Once formed, the trimer, as a unit, oligomerizes with other trimers to form high molecular weight complexes. Although the exact nature of these complexes are unclear, it would appear that a three trimer complex (230 kDa) and a four trimer complex (305 kDa) constitute much of the circulating MBL. It is within the context of these oligomers that MBL performs its functions. After secretion by hepatocytes, oligomerized MBL will both associate with serine proteases (MASP1, 2 & 3) and bind to bacterial carbohydrates. If the MBL complex is small, opsonization of bacreria occurs. If the complex is large, the MASPs are engaged and a complement attack complex is generated, destroying bound bacteria. Human MBL is 63%, 61% and 65% aa identical to mouse, porcine and bovine MBL, respectively.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- human recombinant protein of MBL
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody