Macroglobulin alpha 2
Product Sizes
100 ug
£674.12
101-M560-100UG
About this Product
- SKU:
- 101-M560
- Additional Names:
- A2M; A2MD; CPAMD5; FWP007; S863-7
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 4H44
- Clonality:
- Monoclonal
- Extra Details:
- Human A Alpha2macroglobulin (hA Alpha2M) is a serum glycoprotein that has sequence similarity to other members of the A Alpha2M family including complement components C3, C4 and C5. A Alpha2M is synthesized as a polypeptide of 1474 amino acids with a signal peptide (23 residues). The mature protein is a tetramer (720 kDa) of 4 identicalsubunits (180 kDa), which form two disulfide bondlinked-dimers. As a general and irreversible protease inhibitor implicated in many processes, A Alpha2M is able to inhibit all four classes of proteases by a unique trapping mechanism. The bait region of hA Alpha2M (residues 690-728) contains specific cleavage sites for different proteases. The cleavage of the bait region by a protease induces a conformation change in A Alpha2M, which then traps and forms a covalent bond with the protease. The trapped protease remains active against small peptide substrates but loses its ability to interact with large protein substrates or inhibitors.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Human recombinant alpha-2 macroglobulin
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody