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Antibodies

PDGFR-beta

Product Sizes
100 ug
£674.12
101-M43-100UG
About this Product
SKU:
101-M43
Additional Names:
PDGFRB; JTK12; PDGFR; CD140B; PDGFR1; PDGFR-1
Application:
IHC-Paraffin, Western Blot
Buffer:
PBS
translate.label.attr.clone:
5C37
Clonality:
Monoclonal
Extra Details:
PDGF is a major serum mitogen that can exist as a homo or heterodimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF RA Alpha binds all three PDGF isoforms with high affinity, PDGF RB Beta binds PDGF-BB only with highaffinity. Both PDGF RA Alpha and PDGF RB Beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M CSF, SCF and Flt3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the A Alpha and B Beta receptors is independently regulated in various cell types. Recombinant soluble PDGF RB Beta binds PDGF with high affinity and is potent PDGF antagonist.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
recombinant human PDGFR beta extracellular domain
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody