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Antibodies

DAN

Product Sizes
100 ug
£674.12
101-M374-100UG
About this Product
SKU:
101-M374
Additional Names:
NBL1; NB; DAN; NO3; DAND1; D1S1733E
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
7P12
Clonality:
Monoclonal
Extra Details:
DAN (differential screening-selected gene aberrative in neuroblastoma) was initially identified as a gene whose expression is downregulated in src-transformed rat fibroblasts. Human DAN was isolated from a normal lung cDNA library using mouse DAN as a probe. DAN has now been shown to be a prototypical member of the DAN family of secreted glycoproteins that are putative antagonists for TGFB Beta superfamily proteins. DAN family members share a cysteine-rich domain that is structurally related to the cysteine-knot motif found in TGFB Beta superfamily ligands. There are at least five mammalian DAN family members including DAN, Gremlin/DRM, Cer1 (Cerberusrelated), Dante and PRDC (protein related to DAN and cereberus). Additional DAN family members include Xenopus Cerberus, chick Caronte and C. elegans CeCan 1. The DAN family of proteins are thought to act as antagonists by binding TGFB Beta family ligands and preventing their interactions with signaling receptor complexes. Recombinant human DAN preparationss have been shown to bind BMP4 in a functional ELISA and to inhibit BMP4 mediated bioactivity in ATDC 5 chrondrogenic cells. It is likely the various DAN family members and other TGFB Beta BMP antagonists including Noggin, Chordin, Follistatin and TSG can selectively antagonize the activities of different subsets of TGFB Beta superfamily ligands. These antagonists represent one of the many elaborate regulatory mechanisms that have evolved to control the bioactivities of the TGFB Beta superfamily ligands.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
human recombinant DAN
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody