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Antibodies

CRTAM

Product Sizes
100 ug
£674.12
101-M343-100UG
About this Product
SKU:
101-M343
Additional Names:
CRTAM; CD355
Application:
Flow Cytometry, Western Blot
Buffer:
PBS
translate.label.attr.clone:
21A9
Clonality:
Monoclonal
Extra Details:
Human CRTAM is a 393 amino acid (aa), 80 kDa type I transmembrane glycoprotein. CRTAM is a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production. A role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. IGSF4 is expressed broadly, including on epithelia, neurons, a subset of tonsillar B cells and a rare splenic T zone-restricted BCDA3+ dendritic cell population which interacts with CRTAM.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
human recombinant CRTAM extracellular domain
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody