CRTAM
Product Sizes
100 ug
£674.12
101-M343-100UG
About this Product
- SKU:
- 101-M343
- Additional Names:
- CRTAM; CD355
- Application:
- Flow Cytometry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 21A9
- Clonality:
- Monoclonal
- Extra Details:
- Human CRTAM is a 393 amino acid (aa), 80 kDa type I transmembrane glycoprotein. CRTAM is a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production. A role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. IGSF4 is expressed broadly, including on epithelia, neurons, a subset of tonsillar B cells and a rare splenic T zone-restricted BCDA3+ dendritic cell population which interacts with CRTAM.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- human recombinant CRTAM extracellular domain
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody