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Antibodies

CD86

Product Sizes
100 ug
£674.12
101-M317-100UG
About this Product
SKU:
101-M317
Additional Names:
B7-2; B70; Ly-58
Application:
Block/Inhibit/Neutralise, Flow Cytometry, Western Blot
Buffer:
PBS
translate.label.attr.clone:
7F35
Clonality:
Monoclonal
Extra Details:
B7-1 and B7-2 (CD86), together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B72 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the immunoglobulin superfamily.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
Human recombinant CD86 EC domian
Isotype:
IgG1
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody