CD86
Product Sizes
100 ug
£674.12
101-M317-100UG
About this Product
- SKU:
- 101-M317
- Additional Names:
- B7-2; B70; Ly-58
- Application:
- Block/Inhibit/Neutralise, Flow Cytometry, Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 7F35
- Clonality:
- Monoclonal
- Extra Details:
- B7-1 and B7-2 (CD86), together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B72 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the immunoglobulin superfamily.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- Human recombinant CD86 EC domian
- Isotype:
- IgG1
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody