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Antibodies

Cathepsin L

Product Sizes
100 ug
£674.12
101-M250-100UG
About this Product
SKU:
101-M250
Additional Names:
CTSL1; MEP; CATL; CTSL
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
6M17
Clonality:
Monoclonal
Extra Details:
Cathepsin L is a lysosomal cysteine protease expressed in most eukaryotic cells. Cathepsin L is known to hydrolyze a number of proteins, including the proform of urokinasetype plasminogen activator, which is activated by Cathepsin L cleavage. Cathepsin L has also been shown to proteolytically inactivate A Alpha1 anti trypsin and secretory leucoprotease inhibitor, two major protease inhibitors of the respiratory tract. These observations, combined with the demonstration of increased Cathepsin L activity in the epithelial lining fluid of the lungs of emphysema patients, have led to the suggestion that the enzyme may be involved in the progression of this disease. Cathepsin L has also been identified as a major excreted protein of transformed fibroblasts, indicating the enzyme could be involved in malignant tumor growth. Human Cathepsin L activity is greatest under mildly acidic conditions, from pH 4.5 to 6.5. The stability of the enzyme decreases at higher pH values.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
recombinant human Cathepsin-L
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody