Cathepsin A
Product Sizes
100 ug
£674.12
101-M244-100UG
About this Product
- SKU:
- 101-M244
- Additional Names:
- CTSA; GSL; GLB2; NGBE; PPCA; PPGB
- Application:
- Western Blot
- Buffer:
- PBS
- translate.label.attr.clone:
- 14H2
- Clonality:
- Monoclonal
- Extra Details:
- Cathepsin A/lyososomal carboxypeptidase A is a member of the serine carboxypeptidase family. Cathepsin A is a multifunctional enzyme that expresses deaminidase and esterase activities at neutral pH and carboxypeptidase activity at acidic pH. Also known as protective protein, its association with B Betagalactosidase (B Betagal) and neuraminidase is essential for B Betagal stability and neuraminidase activation in the lysosomes. Inherited deficiency of Cathepsin A causes the lysosomal storage disorder galactosialidosis, characterized by a combined secondary deficiency of B Betagal and neuraminidase. Cathepsin A is capable of hydrolyzing a variety of bioactive peptide hormones including tachykinins, indicating that extralysosomal Cathepsin A plays a role in regulation of functions of these molecules. Cathepsin A is synthesized as a singlechain precursor and processed into heavy (32 kDa) and light (20 kDa) chains, which are linked by disulfide bonds.
- Formulation:
- lyophilized
- Host:
- Mouse
- Immunogen:
- recombinant human Cathepsin-A
- Isotype:
- IgG2
- Purification:
- Protein G Purified
- Reactivities:
- Human
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- ReliaTech
- Type:
- Antibody: Monoclonal Antibody