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Antibodies

Cathepsin A

Product Sizes
100 ug
£674.12
101-M244-100UG
About this Product
SKU:
101-M244
Additional Names:
CTSA; GSL; GLB2; NGBE; PPCA; PPGB
Application:
Western Blot
Buffer:
PBS
translate.label.attr.clone:
14H2
Clonality:
Monoclonal
Extra Details:
Cathepsin A/lyososomal carboxypeptidase A is a member of the serine carboxypeptidase family. Cathepsin A is a multifunctional enzyme that expresses deaminidase and esterase activities at neutral pH and carboxypeptidase activity at acidic pH. Also known as protective protein, its association with B Betagalactosidase (B Betagal) and neuraminidase is essential for B Betagal stability and neuraminidase activation in the lysosomes. Inherited deficiency of Cathepsin A causes the lysosomal storage disorder galactosialidosis, characterized by a combined secondary deficiency of B Betagal and neuraminidase. Cathepsin A is capable of hydrolyzing a variety of bioactive peptide hormones including tachykinins, indicating that extralysosomal Cathepsin A plays a role in regulation of functions of these molecules. Cathepsin A is synthesized as a singlechain precursor and processed into heavy (32 kDa) and light (20 kDa) chains, which are linked by disulfide bonds.
Formulation:
lyophilized
Host:
Mouse
Immunogen:
recombinant human Cathepsin-A
Isotype:
IgG2
Purification:
Protein G Purified
Reactivities:
Human
Shipping Conditions:
Ambient
Storage Conditions:
-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:
ReliaTech
Type:
Antibody: Monoclonal Antibody